Crystallopathies

<p>This episode is about the pathophysiology on crystallopathies. The cellular pathways involved unify multiple concepts and multiple branches of medicine, from toxicology to cardiology to rheumatology and oncology.</p> <p>Heme Review YouTube Channel: <a href="https://www.youtube.com/channel/UCNSoNc9s67nfOGlCXSu5VsA">https://www.youtube.com/channel/UCNSoNc9s67nfOGlCXSu5VsA</a></p> <p>References:</p> <p>[0] Crystallopathies. N Engl J Med 2016; 374:2465-2476. <a href="https://www.nejm.org/doi/full/10.1056/NEJMra1601611">https://www.nejm.org/doi/full/10.1056/NEJMra1601611</a></p> <p>[1] Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. <em>Cell Death &amp; Disease.</em> V<strong>olume&nbsp;10</strong>, Article&nbsp;number:&nbsp;128 (2019). <a href="https://www.nature.com/articles/s41419-019-1413-8">https://www.nature.com/articles/s41419-019-1413-8</a></p> <p>[2] The Inflammasome. Molecular Cell. VOLUME 10, ISSUE 2, P417-426, AUGUST 01, 2002. <a href="https://www.cell.com/molecular-cell/fulltext/S1097-2765(02)00599-3">https://www.cell.com/molecular-cell/fulltext/S1097-2765(02)00599-3</a></p> <p>[3] Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization. Nat Immunol. 2008 Aug; 9(8): 847–856. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834784/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834784/</a></p> <p>[4] Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer. Cancer Res 2020;80:1088–101. <a href="https://cancerres.aacrjournals.org/content/80/5/1088">https://cancerres.aacrjournals.org/content/80/5/1088</a></p>