TWiV 830: A culture of resistance

<p>TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination <em>in vitro</em> would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://alandove.com/">Alan Dove</a>, <a href="http://mgm.ufl.edu/profile/condit-rich/">Rich Condi</a><a href="http://enterovirus.net/">t</a>, and <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a></p> <iframe src= "https://html5-player.libsyn.com/embed/episode/id/21073769/height/90/theme/custom/autoplay/no/autonext/no/thumbnail/yes/preload/no/no_addthis/no/direction/backward/render-playlist/no/custom-color/166899/" width="100%" height="95" allowfullscreen= "allowfullscreen"></iframe> <p>Click arrow to play<br /> Download <a href= "http://traffic.libsyn.com/twiv/TWiV830.mp3">TWiV 830</a> (67 MB .mp3, 112 min)<br /> Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>Spike protein inhibition of <a href= "https://www.mdpi.com/1999-4915/13/10/2056">V(D)J recombination</a> <em>in vitro</em> (Viruses)</li> <li><a href= "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009929"> Evolutionary predictability</a> of SARS-CoV-2 (PLoS Path)</li> <li><a href="https://www.microbe.tv/twiv/twiv-830-letters/">Letters read</a> on TWiV