TWiV 819: How to stall a copy machine

<p>TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://alandove.com/">Alan Dove</a>, <a href="http://mgm.ufl.edu/profile/condit-rich/">Rich Condi</a><a href="http://enterovirus.net/">t</a>, and <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>How remdesivir <a href= "https://www.nature.com/articles/s41467-020-20542-0">stalls the SARS-CoV-2 polymerase</a> (Nat Comm)</li> <li>Movie of <a href= "https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-20542-0/MediaObjects/41467_2020_20542_MOESM4_ESM.mp4"> polymerase stalling</a> (Nat Comm)</li> <li><a href= "https://www.jbc.org/article/S0021-9258(17)50437-8/fulltext">Second mechanism</a> of remdesivir inhibition (J Biol Chem)</li> <li>Watson Crick <a href= "https://collection.sciencemuseumgroup.org.uk/objects/co146411/crick-and-watsons-dna-molecular-model-molecular-model"> molecular model</a> (Science Museum Group)</li> <li><a href="https://www.microbe.tv/twiv/twiv-819-letters/">Letters read</a> on TWiV 819</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Kathy –</strong> <a href= "https://greatscience.com/">Great Lakes Science Center, Cleveland</a><br /> <strong>Rich</strong> – <