TWiV 796: The vary hungry spike with Paul and Theodora

<p>Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://www.trichinella.org/">Dickson Despommier</a>, <a href= "http://mgm.ufl.edu/profile/condit-rich/">Rich Condit</a>, and <a href="http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Guests: <a href= "https://www.rockefeller.edu/our-scientists/heads-of-laboratories/956-paul-bieniasz/"> Paul Bieniasz</a> and <a href= "https://www.rockefeller.edu/our-scientists/research-affiliates/5609-theodora-hatziioannou/"> Theodora Hatiziiouannou</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>High genetic barrier for SARS-CoV-2 <a href= "https://www.biorxiv.org/content/10.1101/2021.08.06.455491v1">antibody escape</a> (bioRxiv)</li> <li><a href="https://pubmed.ncbi.nlm.nih.gov/34126625/">Enhanced antibody</a> one year after COVID-19 (Nature)</li> <li><a href="https://www.microbe.tv/twiv/twiv-796-letters/">Letters read</a> on TWiV 796</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Dickson</strong> – <a href= "https://lasers.llnl.gov/">NIF and Photon Science</a>: fusion reaction generates 1.3 MJ<br /> <strong>Brianne</strong> – <a href= "https://www.youtube.com/watch