TWiV 742: De-fusing COVID-19

<p>TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href="http://www.alandove.com/">Alan Dove</a>, <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, and <a href= "http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>TMEM16 inhibitors block SARS-CoV-2 driven <a href= "https://www.nature.com/articles/s41586-021-03491-6">syncytium formation</a> (Nature)</li> <li><a href="https://www.microbe.tv/twiv/twiv-742-letters/">Letters read</a> on TWiV 742</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>Brianne</strong> – <a href= "https://www.bmj.com/content/373/bmj.n657">COVID-19: a disaster five years in the making</a><br /> <strong>Alan</strong> – <em><a href="https://amzn.to/2Rr5rwr">The Tyranny of Merit</a></em><br /> <strong>Rich</strong> – <a href= "https://www.nytimes.com/2021/04/09/opinion/racism-covid-vaccine.html"> Racism Makes Me Question Everything. I Got the Vaccine Anyway</a><br /> <strong>Kathy</strong> – The Transcontinental Burrito Tunnel<br /> <strong>Vincent</strong> – <a href= "https://www.youtube.com/channel/UCoZ7xYyx3UjG6Xus1l73Vww">Trudy Rey’s YouTube Channel</a></p> <h3>Lis