TWiV 740: Complementation will get you everywhere

<p>The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href="http://www.trichinella.org/">Dickson Despommier</a>, <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a>, and <a href= "http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li><a href="https://nido2021.nl/scientific-program.php">NIDO 2021 Symposium</a></li> <li>ASV hosts free COVID-19 Vaccine Education Town Halls (register <a title="https://asv.org/education/" href= "https://asv.org/education/">here</a>)</li> <li><a href= "https://careers.umich.edu/job_detail/194512/research_lab_specialist_inter"> Research position</a> in Spindler laboratory</li> <li><a href= "https://science.sciencemag.org/content/320/5884/1784">Attenuation of poliovirus</a> by codon deoptimization (Science)</li> <li>Rescue of <a href= "https://www.pnas.org/content/118/13/e2020969118">codon-deoptimized RSV</a> by large deletions (PNAS)</li> <li><a href="https://www.microbe.tv/twiv/twiv-740-letters/">Letters read</a> on TWiV 740</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <h3>Weekly Picks</h3> <p><strong>