TWiV 714: The shape of spike with Jason McLellan

<p>Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href="http://www.trichinella.org/">Dickson Despommier</a>, <a href="http://www.alandove.com/">Alan Dove</a>, <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, and <a href="http://www.enterovirus.net/">Amy Rosenfeld</a></p> <p>Guest: <a href="https://www.mclellanlab.org/research">Jason McLellan</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>Prefusion <a href= "https://pubmed.ncbi.nlm.nih.gov/32075877/">spike structure</a> (Science)</li> <li>Neutralization of VOC by vaccine induced antibodies: <a href= "https://www.biorxiv.org/content/10.1101/2021.01.25.427948v1">Moderna</a> and <a href= "https://www.biorxiv.org/content/10.1101/2021.01.27.427998v1">Pfizer</a></li> <li>Novavax COVID-19 vaccine <a href= "https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3"> phase 3 results</a> (Novavax)</li> <li>J&J COVID-19 vaccine <a href= "https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial"> phase 3 results</a> (J&J)</li> <li><a href= "https://virological.org/t/phylogenetic-evidence-that-b-1-1-7-has-been-circul