TWiV 703: Does dose matter?

<p>On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a>, and <a href= "http://twitter.com/bioprofbarker">Brianne Barker</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a></p> <p>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li>BSL-3 <a href= "https://opportunities.columbia.edu/en-us/job/510343/assistant-manager-hcl-bsl3">Assistant Manager position</a></li> <li>Follow authorized <a href= "https://www.fda.gov/news-events/press-announcements/fda-statement-following-authorized-dosing-schedules-covid-19-vaccines"> vaccine dosing schedule</a> (FDA)</li> <li>Mina suggests <a href= "https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html"> one vaccine dose</a> (NY Times)</li> <li>UK decision document on vaccine dose (<a href= "https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/949772/UKPAR_COVID_19_Vaccine_AstraZeneca_05.01.2021.pdf">pdf</a>)</li> <li>Ct linked to <a href= "https://pubmed.ncbi.nlm.nih.gov/33349793/">COVID-19 mortality</a> (Open Forum Inf Dis)</li> <li><a href= "https://www.nature.com/articles/s41467-020-20439-y">Dose-dependent</a> infection of ferrets (Nat Comm)</l