TWiV 676: Tragic gene flow from Neanderthals

<p>In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello,</a> <a href= "http://www.mgm.ufl.edu/faculty/faculty-home-pages/condit-richard-c/"> Rich Condit</a>, <a href= "https://sites.google.com/a/umich.edu/spindler-lab/">Kathy Spindler</a> and <a href= "http://www.twitter.com/BioProfBarker">Brianne Barker</a></p> <p>Subscribe (free): <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784">iTunes</a>, <a href="https://www.google.com/podcasts?feed=aHR0cDovL3R3aXYubWljcm9iZXdvcmxkLmxpYnN5bnByby5jb20vdHdpdg%3D%3D">Google Podcasts</a>, <a href= "http://twiv.microbeworld.libsynpro.com/twiv">RSS</a>, <a href="http://eepurl.com/Gcw59">email</a>Become a <a href= "https://www.microbe.tv/contribute">patron</a> of TWiV!</p> <h3><strong>Links for this episode</strong></h3> <ul> <li><a href="https://www.nejm.org/doi/10.1056/NEJMoa2020283">Genome wide association study</a> of severe COVID-19 (NEJM)</li> <li>Major <a href= "https://www.nature.com/articles/s41586-020-2818-3">genetic risk factor</a> for severe COVID-19 inherited from Neanderthals (Nature)</li> <li>COVID-19 <a href= "https://pubmed.ncbi.nlm.nih.gov/32404885/">host genetics initiative</a> (Eur J Hum Gen)</li> <li>Prolonged <a href= "https://urldefense.proofpoint.com/v2/url?u=https-3A__pubmed.ncbi.nlm.nih.gov_33089317_&d=DwMFAg&c=G2MiLlal7SXE3PeSnG8W6_JBU6FcdVjSsBSbw6gcR0U&r=o4snVIQZ0CVuLGpZvqFOP4ToVfgjBKFWQW4Gx6mIfA4&m=OmiWo6kUeVgjvprlKSxtZAhC59oZDpo82QJqIzz_BgY&s=qBmPRFXwM5KO2GUked_R121-g7wpDYNo1eYu93y6NXo&e="> SARS-CoV-2 shedding</a> in immunocompromised host (J Inf Dis)</li> <li>Krugman on <a href= "https://www.nytimes.com/2020/10/26/opinion/trump-coronavirus-climate-change.html?action=click&module=Opinion&pgtype=Homepage"> Barrington Declaration</a> (