TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease

<p>TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://twitter.com/orilieberman">Ori Lieberman</a>, <a href="http://twitter.com/jasonsynaptic">Jason Shepherd</a>, <a href= "https://med.nyu.edu/research/kang-lab/team">Timothy Cheung</a>, and Vivianne Morrison</p> <p>Subscribe (free): <a href= "https://podcasts.apple.com/us/podcast/this-week-in-neuroscience/id1485118950">Apple Podcasts</a>, <a href= "https://podcasts.google.com/feed/aHR0cHM6Ly90d2luMS5saWJzeW4uY29tL3Jzcw">Google Podcasts</a>, <a href= "https://twin1.libsyn.com/rss">RSS</a>, email</p> <h3 id="links-for-this-episode">Links for this episode</h3> <ul id="block-d6528a9f-b922-4b95-af3d-cdfefa7d09fb"> <li>Gut-brain <a href= "https://doi.org/10.1016/j.neuron.2019.05.035">alpha-synuclein transport</a> in PD (Neuron)</li> <li>Gut has a <a href= "https://www.cc.com/video/zpjdcg/the-colbert-report-michael-gershon"> mind of its own</a> (Colbert Report)</li> <li>Timestamps by <a href= "http://www.twitter.com/jrrmicro">Jolene</a>. Thanks!</li> </ul> <p>Music is by <a href="http://www.ronaldjenkees.com/">Ronald Jenkees</a></p> <p>Send your neuroscience questions and comments to twin@microbe.tv</p>