Targeting the microbiome to boost your health & longevity

<p><span data-preserver-spaces="true">Join Dr. Jeffrey Gladden in this conversation with Colleen Cutcliffe, Co-Founder and CEO of Pendulum Therapeutics. Colleen earned a PhD in Biochemistry and Microbiology from Johns Hopkins University, did her postdoctoral work at Northwestern University, and is on a mission to make millions healthier through microbiome-targeted medical probiotics. In this episode, they discuss her personal journey to the creation and development of Pendulum, how it works to treat conditions like metabolic syndrome, inflammation and neurodegeneration, and the ways in which treating and maintaining a healthy microbiome could be a hack to successful aging and disease-free longevity. If you are looking for a natural route to overall health and optimization, this episode is for you.</span></p> <p> </p> <p><span data-preserver-spaces="true">Show notes:</span></p> <p><span data-contrast="auto">Dr. Gladden introduces Colleen, and she introduces herself, gives us her personal journey to the creation and development of Pendulum, her personal connection to it. (1:30)</span> </p> <p> </p> <p><span data-contrast="auto">Colleen talks creating products that have the efficacy of a drug but the safety of a probiotic. (2:40)</span> </p> <p> </p> <p><span data-contrast="auto">Colleen mentions a study that showed how kids taking antibiotics before six months of age are systematically more prone to diseases like obesity and type two diabetes as they age. Dr. Gladden mentions how antibiotics affect children. (4:00)</span> </p> <p> </p> <p><span data-contrast="auto">Colleen tells us how butyrate is a small molecule with a really important role in a variety of different things. Our colon cells, for example, are the only cells in our entire body that use butyrate as their source of energy, as opposed to glucose. (6:10)</span> </p> <p> </p> <p><span data-contrast="auto">Dr. Gladden explains how the fiber metabolism generates butyrate that feeds the intestinal lining, including how fascinating it is that this butyrate i