SynBio and mRNA [Jason Kelly]

<p>Listen to Business Breakdowns: <a href="https://www.joincolossus.com/episodes/56584905/kelly-moderna-the-software-of-life?tab=transcript">https://www.joincolossus.com/episodes/56584905/kelly-moderna-the-software-of-life</a></p><p><br><strong><br>Transcript<br></strong><br></p><p><strong><br>Jesse: </strong><a href="https://www.joincolossus.com/episodes/56584905/kelly-moderna-the-software-of-life?startTime=363&amp;btp=dc63d6e4"><strong>[00:06:03]</strong></a><strong> And if you back up on the DNA, like this notion that it's four letters of code, can you walk us through the history of that? How did that come to be? Who's the father or mother of that? Where did that come to be? And then how did it evolve to today where it sounds like you're able to essentially program your own things in a lab and create them?<br></strong><br></p><p><strong><br>Jason: </strong><a href="https://www.joincolossus.com/episodes/56584905/kelly-moderna-the-software-of-life?startTime=379&amp;btp=dc63d6e4">[00:06:19]</a> The first thing to realize is this is just a miracle of biology that it works this way in the first place. Get back four billion years of evolution, here's the magic. When we invented computers, we had to come up with a way to copy things. Do you want to send a file or make... And we realize that instead of like a record player, which is an analog thing, little bumps on the record define the data, but those can move around and change. If you really want to transfer information with high fidelity, make a CD and make it zeros and ones, digital, because every time you copy it perfectly.</p><p><br>Biology figured out the exact same thing. When you have a kid, you want to transmit heritable information, you want your genes to move on to the kid. And the way that biology figured out how to pass information across generations, digital. A, T, Cs, and Gs. It just happens to do it, not with magnetic bits on a computer, but with actual chemicals.</p><p><strong><br>Jesse: </strong><a href="https://www.joincolossus.com/episode