Reversing Skin Aging at the Cellular Level (Carolina Reis Oliveira and Alessandra Zonari, OneSkin)

<p>Dr. Carolina Reis Oliveira and Dr. Alessandra Zonari are the co-founders of OneSkin, a company developing science-backed skincare products to reverse skin aging at the cellular level. In this episode, Carolina and Alessandra tell host Dr. Chris Patil how OneSkin is leveraging recent advances in longevity science to create novel peptides that target senescent cells and inflammation in aged skin. Their lead ingredient, OS-1, is a peptide capable of reducing biological age and senescence burden in human skin models.They explain their rigorous discovery process, including screening peptide libraries in cellular models of skin aging, which were described in a recent paper in <a href="https://doi.org/10.1038/s41514-023-00109-1" rel="noopener noreferrer" target="_blank">Nature Aging</a>. Next, they share how they translated this scientific research into an effective, consumer-friendly skincare product line and brand. Listeners will gain insights into OneSkin's unique approach bridging cosmetics and cutting-edge geroscience.</p><p><strong>Key topics:</strong></p><ul><li>Why skin health and appearance are important markers of overall aging</li><li>The cellular and molecular changes underlying skin aging</li><li>How most skincare products focus on temporary effects vs. targeting root causes</li><li>Screening peptide libraries in cellular models to discover senolytic/senomorphic candidates</li><li>Discovery and testing of lead peptide OS-1 in 3D skin models and human trials</li><li>Validating safety and efficacy to meet cosmetics regulatory requirements</li><li>Launching a science-backed skincare brand and resonating with educated consumers</li><li>Ongoing R&amp;D to expand into new anti-aging applications and delivery methods</li></ul><br/><p><strong>Quotes:</strong></p><p><em>Quotes have been lightly edited for clarity.</em></p><p>"Obviously, we look at our skin from the lens of aesthetics or of beauty. But our skin is our largest organ, and its main function is to protect our whole body against pathogens and different