PubReading [92] - Progress toward understanding chromosome silencing by Xist RNA - N. Brockdorff, J. Bowness, and G. Wei

<p>The <strong>X inactive-specific transcript</strong> (Xist) gene is the master regulator of X chromosome inactivation in mammals. <strong>Xist</strong> produces a long noncoding (lnc)RNA that accumulates over the entire length of the chromosome from which it is transcribed, recruiting factors to modify under-lying chromatin and silence X-linked genes in cis. Recent years have seen significant progress in identifying important functional elements in Xist RNA, their associated <strong>RNA-binding proteins</strong> (RBPs), and the downstream pathways for chromatin modification and gene silencing. In this review, we summarize progress in understanding both how these pathways function in Xist-mediated silencing and the complex interplay between them. - <a href="http://www.genesdev.org/cgi/doi/10.1101/gad.337196">doi/10.1101/gad.337196</a> - 2022</p>