PubReading [9] - Principles of ubiquitin and SUMO modifications in DNA repair - S. Bergink, S. Jentsch

<p>With the discovery in the late 1980s that the <strong>DNA-repair gene</strong> <strong><em>RAD6</em></strong><em> </em>encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, <strong>ubiquitin</strong> and its cousin <strong>SUMO</strong> are implicated in a range of human diseases, including breast cancer and <strong>Fanconi anaemia</strong>, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways. - NATURE - 2009 -. doi:10.1038/nature07963</p>