PubReading [319] - The Science Behind NMN—A Stable, Reliable NAD+ Activator and Anti-Aging Molecule - Christopher Shade

In June of 2018, the World Health Organization (WHO) released the 11th edition of its <em>International Classification of Diseases, </em>and for the first time added aging. The classification of <strong>aging</strong> as a disease paves the way for new research into novel therapeutics to delay or reverse age-related <strong>illnesses</strong> such as cancer, cardiovascular and metabolic disease, and neurodegeneration. Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with <strong>NAD+ (nicotinamide adenine dinucleotide)</strong>, a coenzyme present in all living cells<em>Integr Med (Encinitas).2020 Feb;19(1):12-14.</em>