![PubReading [290] - Placebo Controls- Now??? - A. Caplan](https://pbcdn.aoneroom.com/image/2025/10/01/7e6046e0a35206382805a998ee97f6e9.jpg)
PubReading [290] - Placebo Controls- Now??? - A. Caplan
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<p>In this era of a <strong>pandemic</strong>, why do we need the <strong>placebo</strong> controls for regulatory agency or Food and Drug Administration (FDA)-approved clinical trials aimed at COVID-19 patients? The answer is always that we have to establish a ruler with a baseline onto which efficacy measurements can be statistically judged.</p><p><a href="https://doi.org/10.1007/s00005-021-00612-x"><em>https://doi.org/10.1007/s00005-021-00612-x</em></a><em> - 2021</em></p>