PubReading [21] - DNA structure from A to B - R.Dickerson and HL. Ng

<p>P. Shing Ho and his colleagues at Oregon State and Berkeley publish in this issue of PNAS an interesting study (1) of <strong>helical structure</strong> in the DNA hexamer GGCGCC, finding that various states that appear to be logical intermediates between <strong>A-DNA </strong>and<strong> B-DNA</strong> can be induced by methylation or bromination of cytosine or by crystal packing. Their results bear on three issues that have been argued over in the past: (<em>i</em>) the differences between A-DNA and B- DNA and <strong>transitions</strong> between them, (<em>ii</em>) the intrinsic sequence-dependent malleability of a DNA duplex, and (<em>iii</em>) the effects of local helix packing on DNA fine-structure. - doi-10.1073-pnas.141238898 - 2001</p>