PubReading [173] - CAR T cell immunotherapy for human cancer - C. June, M. Milone et al.

<p><strong>Adoptive T cell transfer</strong> (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of <strong>immuno-oncology</strong> in preclinical models to the recent commercial approvals of <strong>chimeric antigen receptor</strong> (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.</p><p><em>DOI: 10.1126/science.aar6711 - 2018</em></p>