PubReading [168] - Advances of epigenetic editing - R. Gjaltema and M. Rots

<p><strong>Epigenetic</strong> editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional <strong>reprogramming</strong>. Implementing clustered regularly interspaced short palindromic repeat–dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic <strong>enzymes</strong>. Here, we review the current applications of these epigenetic editing tools in mammals and shed light on biochemical improvements that facilitate versatile applications.</p><p><em>doi.org/10.1016/j.cbpa.2020.04.020 - 2020</em></p>