PubReading [165] - Macrocyclic Metal Complex−DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA - J. Duprey, J. Tucker et al

<p>The direct incorporation of <strong>macrocyclic cyclidene</strong> complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active <strong>copper(II)</strong>-containing strand to distinguish <strong>electrochemically</strong> between all four canonical DNA nucleobases at a single site within a target sequence of DNA.</p><p><em>DOI: 10.1021/jacs.5b11319 - 2015</em></p>