PubReading [142] - Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology - S. Epple, A. El-Sagheer and T. Brown

<p>The <strong>modification</strong> of DNA or RNA <strong>backbones</strong> is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported arti- ficial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleo- tides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into <strong>oligonucleotides</strong> are urgently needed to utilise their full potential in therapeutics, <strong>synthetic biology</strong> and biotechnology.</p><p><em>doi.org/10.1042/ETLS20210169 - 2021</em></p>