PubReading [137] - Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides -K. Beck, P. Nielsen et al

<p>Nucleotide monomers that hold two nucleobases each, i.e. <strong>double- headed</strong> <strong>nucleotides</strong>, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids <strong>(DhNA</strong>), we have prepared three new DhNA <strong>monomers</strong> and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.</p><p>DOI: 10.1039/d1cc03539h - 2021</p>