Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment

<div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even"> <p>Join MitoAction and Dr. Richard Frye to discuss the distinction between primary and secondary mitochondrial diagnosis. Some talking points will include:</p> <ul class="list"> <li>Primary mitochondrial disease (PMD) is ideally diagnosed by a known or indisputably pathogenic mitochondrial or nuclear DNA mutation.</li> <li>Secondary mitochondrial dysfunction (SMD) can be caused by genes encoding either function nor production of the oxphos proteins and accompanies many heriditary non-mitochondrial diseases.</li> <li>Secondary mitochondrial dysfunction (SMD) can also be caused by enviornmental factors.</li> <li>In the absence of the ability to diagnose a primary mitochondrial disease (PMD), mitochondrial dysfunction can be effectively treated with standard treatments for PMD.</li> <li>When the etiology of mitochondrial dysfunction is unknown, re-evaluation for genetic and other causes should be revisited on a regular basis.</li> </ul> </div> </div> </div> <div class="field field-name-field-about-speaker field-type-text-long field-label-above"> <h5 class="field-label">About The Speaker:</h5> <div class="field-items"> <div class="field-item even"> <div class="m_786556036305726668entry-content" dir="auto"> <p>Dr. Richard&nbsp;<span class="il">Frye</span>&nbsp;is a pediatric neurologist and Chief of the Division of Neurodevelopmental Disorders at Phoenix Children's Hospital. &nbsp;He received his MD/PhD from Georgetown University in 1998. He completed a residency in Pediatrics at the University of Miami, Residency in Child Neurology and Fellowship in Behavioral Neurology and Learning Disabilities at Harvard University/Children&rsquo;s Hospital Boston and Fellowship in Psychology at Boston University. He holds board certifications in Pediatrics, and in Neurology with Special Competence in Child Neurology. Dr.&nbsp;<span class="il">Frye</span>&nbsp;is a national l