Podcast 831: O2 Targets

<p><strong>Contributor: Aaron Lessen,MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">R</span><span style="font-weight: 400;">ecent study looked at mechanically ventilated patients in ED and ICU to determine if O2 saturation level impacted patient outcomes</span></li> <li style="list-style: none; display: inline"> <ul> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">2541 patients randomized to one of three target O2 saturation levels</span></li> <li style="list-style: none; display: inline"> <ul> <li style="font-weight: 400;" aria-level="3"><span style= "font-weight: 400;">Low: 90% (Range: 88-92%)</span></li> <li style="font-weight: 400;" aria-level="3"><span style= "font-weight: 400;">Intermediate: 94% (Range: 92-96%)</span></li> <li style="font-weight: 400;" aria-level="3"><span style= "font-weight: 400;">High: 98% (Range: 96-100%)</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Outcome indicators</span></li> <li style="list-style: none; display: inline"> <ul> <li style="font-weight: 400;" aria-level="3"><span style= "font-weight: 400;">Primary: Number of days alive and ventilator free by day 28 of hospital admission</span></li> <li style="font-weight: 400;" aria-level="3"><span style= "font-weight: 400;">Secondary: Mortality at 28 days</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">No significant difference was seen for either primary or secondary outcomes between all three groups at 28 days</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">This study shows that the target oxygenation level  is not likely to significantly impact outcomes in mechanically ventilated patients in the ED</span></li> </ul> <p> </p> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Semler MW, Casey JD, Lloyd BD, et al. Oxygen-Saturati