Podcast 781: Foxglove, Dropsy, and Salvador Dali

<p><strong>Contributor: Chris Holmes, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Foxglove plant contains the cardiac glycoside digoxin  </span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Foxglove leaf potions were once used to treat Dropsy; a historic term for symptoms of heart failure </span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Digoxin, previously used for treating heart failure, works by increases heart contraction strength and slows heart rate</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Of note, the EKG of patient on digitalis may have a ‘Dali Mustache’ appearance</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Digoxin toxicity can lead to a variety of dysrhythmias as well as neurological, GI, and metabolic effects</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Treatment of digoxin toxicity is digoxin-immune fab, which is an antibody that binds digoxin</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">David MNV, Shetty M. Digoxin. [Updated 2021 Dec 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:</span> <a href= "https://www.ncbi.nlm.nih.gov/books/NBK556025/"><span style="font-weight: 400;"> https://www.ncbi.nlm.nih.gov/books/NBK556025/</span></a></p> <p><span style="font-weight: 400;">Cummings ED, Swoboda HD. Digoxin Toxicity. [Updated 2021 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470568/?report=classic</span></p> <p><em><span style="font-weight: 400;">Summarized by Kirsten Hughes, MS4 | Edited by John Spartz MS4 & Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-weight: 400;">The Emer