Podcast 749: PCC for Me?

<strong>Contributor: Nick Tsipis, MD</strong> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Prothrombin complex concentrate (Kcentra)  and Vitamin K are used to reverse life-threatening bleeds in patients on warfarin (Coumadin)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Factors II, VII, IX, and X are included in four-factor PCC</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">PCC/Kcentra dosing is 500-2000 units based on INR and patient weight</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">PROPER3 RCT was a non-inferiority trial done to evaluate standardized dosing of PCC/Kcentra versus variable dosing based on INR and weight</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Looked at end-points to assess hemostasis, but ultimately this trial did not show non-inferiority of standardized dosing compared to variable dosing</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Abdoellakhan RA, Khorsand N, Ter Avest E, et al. Fixed Versus Variable Dosing of Prothrombin Complex Concentrate for Bleeding Complications of Vitamin K Antagonists-The PROPER3 Randomized Clinical Trial. Ann Emerg Med. 2022;79(1):20-30. doi:10.1016/j.annemergmed.2021.06.016</span></p> <p><em><span style="font-weight: 400;">Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minute is excited to announce that we are now offering</span> <em><span style="font-weight: 400;">AMA PRA Category 1 credits™</span></em> <span style="font-weight: 400;">via online course modules. To access these and for more information, visit our website at</span> <a href= "https://emergencymedicalminute.org/cme-courses/"><span style= "font-weight: 400;">https://emergencymedicalminute.org/cme-course