Podcast 663:  Down Syndrome

<p><strong>Contributor:  Alicia Oberle, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Down Syndrome with Trisomy 21 have three copies of chromosome 21</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Current birth rates are around 1 in 700 births </span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Average life span 25 years in 1980, today the average life span is 60 years of age</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Patients with Down syndrome require additional therapies in the first 3 years due to developmental delays</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">They also have increased risk for childhood leukemias, seizures, hypothyroidism, celiac disease, and early-onset Alzheimers</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Half have a cardiac defect requiring surgery at birth</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Tsou AY, Bulova P, Capone G, et al. Medical Care of Adults With Down Syndrome: A Clinical Guideline. JAMA. 2020;324(15):1543–1556. doi:10.1001/jama.2020.17024</span></p> <p><em><span style="font-weight: 400;">Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minute is excited to announce that we are now offering</span> <em><span style="font-weight: 400;">AMA PRA Category 1 credits™</span></em> <span style="font-weight: 400;">via online course modules. To access these and for more information, visit our website at</span> <a href= "http://www.emergencymedicalminute.com/cme-courses"><span style= "font-weight: 400;">www.emergencymedicalminute.com/cme-courses/</span></a> <span style="font-weight: 400;">and create an account. </span></p> <p><a hre