Podcast 662: Droperidol for Sedation

<p><strong>Contributor:  Aaron Lessen, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Droperidol for sedation in agitated patients in the emergency department was studied compared to ziprasidone (Geodon) and lorazepam (Ativan)</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Double-blinded RCT showed droperidol was 65% effective to get patients to a good level of sedation in 15 minutes compared to ativan and geodon which were 25-35% effective</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Droperidol had less respiratory depression and prolongation of the QT compared to Ativan and Geodon</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">Martel ML, Driver BE, Miner JR, Biros MH, Cole JB. Randomized Double-blind Trial of Intramuscular Droperidol, Ziprasidone, and Lorazepam for Acute Undifferentiated Agitation in the Emergency Department. Acad Emerg Med. 2021 Apr;28(4):421-434. doi: 10.1111/acem.14124. Epub 2020 Oct 5. PMID: 32888340.</span></p> <p><em><span style="font-weight: 400;">Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD</span></em></p>