Podcast 626: Updated Gonorrhea Treatment

<p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">The CDC has made new formal recommendations for treating Gonorrhea due to increasing resistance to Rocephin and Azithromycin.</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">New recommendations:</span></li> <li style="list-style: none; display: inline"> <ul> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Confirmed gonorrhea: Ceftriaxone 500 mg once</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Empiric treatment: Ceftriaxone 500 mg once followed by 7 days Doxycycline 100 mg BID</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">No longer using Azithromycin due to high resistance</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Second line:</span></li> <li style="list-style: none; display: inline"> <ul> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Gentamycin IM</span></li> <li style="font-weight: 400;" aria-level="2"><span style= "font-weight: 400;">Cefixime 800 mg oral</span></li> </ul> </li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Pharyngeal involvement has high resistance rates to second line agents and ceftriaxone is strongly preferred</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400;">St. Cyr S, Barbee L, Workowski KA, et al. Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1911–1916. DOI:</span> <a href= "http://dx.doi.org/10.15585/mmwr.mm6950a6"><span style= "font-weight: 400;">http://dx.doi.org/10.15585/mmwr.mm6950a6.</span></a></p> <p><em><span style="font-weight: 400;">Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD</span></em></p> <p> </p> <p><span style="font-size: 10pt;"><span style= "font-weight: