Podcast 624: Timing and Tips on Sepsis

<p><strong>Contributor: Don Stader, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Time can be an important factor in outcomes regarding sepsis including mortality</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">Emphasis has grown on early administration of antibiotics and IV fluids in sepsis</span></li> <li style="font-weight: 400;" aria-level="1"><span style= "font-weight: 400;">However, early initiation of vasopressors for hypotensive patients may have significant mortality benefit as well</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Hayden GE, Tuuri RE, Scott R, et al.</span> <a href="https://pubmed.ncbi.nlm.nih.gov/26386734/"><span style= "font-weight: 400;">Triage sepsis alert and sepsis protocol lower times to fluids and antibiotics in the ED.</span></a> <em><span style="font-weight: 400;">Am J Emerg Med</span></em><span style="font-weight: 400;">. 2016;34(1):1-9. doi:10.1016/j.ajem.2015.08.039</span></span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Colling KP, Banton KL, Beilman GJ.</span> <a href="https://pubmed.ncbi.nlm.nih.gov/29336676/"><span style= "font-weight: 400;">Vasopressors in Sepsis</span></a><span style= "font-weight: 400;">.</span> <em><span style= "font-weight: 400;">Surg Infect (Larchmt)</span></em><span style= "font-weight: 400;">. 2018;19(2):202-207. doi:10.1089/sur.2017.255</span></span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Colon Hidalgo D, Patel J, Masic D, Park D, Rech MA.</span> <a href= "https://pubmed.ncbi.nlm.nih.gov/31731173/"><span style= "font-weight: 400;">Delayed vasopressor initiation is associated with increased mortality in patients with septic shock.</span></a> <span style="font-weight: 400;">J Crit Care. 2020 Feb;55:145-148. doi: 10.1016/j.jcrc.2019.11.004. Epub 2019 Nov 9. PMID: 31731173.</span></s