Podcast 612: Origin of Vaccines

<p><strong>Contributor: Dave Rosenberg, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The potential of vaccinations was first observed in the late 1600s when Jenner observed people who had cowpox never contracted smallpox, so he inoculated people with cowpox to see if it prevented smallpox, and…</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Years later, Louis Pasteur inoculated chickens with cholera after his assistant accidently created the first live attenuated vaccine by creating a weakened bacteria when he left the bacteria out while he went on vacation</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Pasteur observed that exposing chickens to full strength cholera after the exposure with the weakened bacteria led to minimal or no ill effects</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Stewart AJ, Devlin PM.</span> <a href= "https://pubmed.ncbi.nlm.nih.gov/16176833/"><span style= "font-weight: 400;">The history of the smallpox vaccine</span></a><span style="font-weight: 400;">. J Infect. 2006 May;52(5):329-34. doi: 10.1016/j.jinf.2005.07.021. Epub 2005 Sep 19. PMID: 16176833.</span></span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Hajj Hussein I, Chams N, Chams S, El Sayegh S, Badran R, Raad M, Gerges-Geagea A, Leone A, Jurjus A.</span> <a href="https://pubmed.ncbi.nlm.nih.gov/26636066/"><span style= "font-weight: 400;">Vaccines Through Centuries: Major Cornerstones of Global Health.</span></a> <span style="font-weight: 400;">Front Public Health. 2015 Nov 26;3:269. doi: 10.3389/fpubh.2015.00269. PMID: 26636066; PMCID: PMC4659912.</span></span></p> <p><span style="font-size: 10pt;"><em><span style= "font-weight: 400;">Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD</span></em></span></p> <p> </p> <p><span style="font-weight: 400;">The Emergency Medical Minut