Podcast 540:   Zyprexa 

<p><strong>Contributor:  Don Stader, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;"><span style= "font-weight: 400;">Olanzapine (Zyprexa) is an atypical antipsychotic that can be used in a similar fashion to haloperidol for pain and nausea, including that with abdominal pain and headaches</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Olanzapine can be administered as an oral disolving tablets, intramuscular or intravenous injection</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Because Zyprexa is an atypical antipsychotic, it has a lower risk for tardive dyskinesia and akathisia </span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Olanzapine may cause transient rises in glucose and should be considered when contemplating use in a diabetic</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-weight: 400; font-size: 10pt;">Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults.Sutherland A, Naessens K, Plugge E, Ware L, Head K, Burton MJ, Wee B. Cochrane Database Syst Rev. 2018;9:CD012555. Epub 2018 Sep 21. </span></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Silberstein, S.D., Peres, M.F., Hopkins, M.M., Shechter, A.L., Young, W.B. and Rozen, T.D. (2002), Olanzapine in the Treatment of Refractory Migraine and Chronic Daily Headache. Headache: The Journal of Head and Face Pain, 42: 515-518. doi:</span><a href= "https://doi.org/10.1046/j.1526-4610.2002.02126.x"><span style= "font-weight: 400;">10.1046/j.1526-4610.2002.02126.</span></a></span></p> <p><span style="font-size: 10pt;"><em><span style= "font-weight: 400;">Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD</span></em></span></p> <p><br /> <br /></p>