Podcast 533:  Hypoglycemia

<p><strong>Contributor: Dylan Luyten, MD</strong></p> <p><strong>Educational Pearls:</strong></p> <ul> <li style="font-weight: 400;"><span style= "font-weight: 400;">Insulin related hypoglycemia can vary from a brief transient effect from short-acting forms (i.e. insulin lispro) to prolonged from long acting (i.e. insulin glargine), and will require different treatment and/or observation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Of oral glycemic agents, sulfonylureas are a common culprit while metformin is rarely a cause</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Sulfonylureas also deserve attention because in pediatric patients, they can be lethal even with a single ingestion, but also can cause severe hypoglycemia in adults</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Hypoglycemia in non-diabetics usually occurs in the malnourished, or in those with liver or adrenal disease</span></li> </ul> <p><strong>References</strong></p> <p><span style="font-size: 10pt;"><span style= "font-weight: 400;">Klein-Schwartz W, Stassinos GL, Isbister GK. Treatment of sulfonylurea and insulin overdose.</span> <em><span style="font-weight: 400;">Br J Clin Pharmacol</span></em><span style="font-weight: 400;">. 2016;81(3):496–504. doi:10.1111/bcp.12822</span></span></p> <p><span style="font-weight: 400; font-size: 10pt;">Tourkmani AM, Alharbi TJ, Rsheed AMB, AlRasheed AN, AlBattal SM, Abdelhay O, Hassali MA, Alrasheedy AA, Al Harbi NG, Alqahtani A. Hypoglycemia in Type 2 Diabetes Mellitus patients: A review article. Diabetes Metab Syndr. 2018 Sep;12(5):791-794. doi: 10.1016/j.dsx.2018.04.004. Epub 2018 Apr 12.</span></p> <p><span style="font-size: 10pt;"><em><span style= "font-weight: 400;">Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD</span></em></span></p> <p><br /> <br /></p>