May 2020 Discover CircRes

<p>This month on Episode 12 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the May 8 issue of Circulation Research and gives listeners an inside scoop of the cutting edge ideas in the May 22nd Compendium on Obesity. This episode also features an in-depth conversation with Dr Eduardo Marbán concerning COVID-19 and its effects on the heart.</p> <p> </p> <p>Article highlights:<br />  </p> <p>Roberts et al.  <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.315708">LYN Regulates Monocyte Heterogeneity and Lifespan</a></p> <p>Lu, et al. <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316288">Acute Hyperglycemia Activates CaMKII-ROS Pathway</a></p> <p>Yan, et al. <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316251">Epicardium and Atrial Cardiomyopathy</a></p> <p>Transcript<br /> Dr Cindy St. Hilaire: Hi. Welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. Today, I'm going to share with you articles selected from the May 8th issue of Circulation Research as well as give you a hint at the cutting-edge ideas in the May 22nd Compendium on Obesity. We'll also have discussion with Dr Eduardo Marbán from the Smidt Heart Institute at Cedar Sinai Medical Center about his Review on COVID-19 and its effects on heart. So, first the highlights.</p> <p>The first article I'm sharing with you is titled Deep Phenotyping by Mass Cytometry and Single Cell RNA Sequencing reveals LYN Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan. The first authors are Morgan Roberts and Maunish Barvalia and the corresponding author is Kenneth Harder and they're from the University of British Columbia. Monocytes can be separated into two main groups, conventional monocytes which enter tissues from the bloodstream and differentiate into macrophages, and patrollin