LSD & Psychedelic Chemistry

<p>Lysergic acid diethylamide (LSD) is one of fungi’s most well known chemical analogues. Today we bring you a leading scientist, Dr. David Nichols who speaks to the history, chemistry, legality and so much more of this notable compound. </p><p><b> Topics covered:</b></p><ul><li>David Nichol’s career pursuing psychedelic pharmacology</li><li>Patent litigation, especially with psychedelic constituents </li><li>Lab testing for new psychedelic analogues in rats</li><li>Bureaucracy of working with Schedule I substances</li><li>How to synthesize LSD</li><li>LSD’s physical characteristics, structure and fluorescence</li><li>What happens to the LSD molecule when you adjust minute aspects, and what that tells us about itself</li><li>Structural similarities and differences in an array of psychedelic molecules / chemical ‘templates’ for psychoactive compounds</li><li>Neuro-mechanics of LSD and other entheogenic compounds</li><li>Evolution and function of serotonin receptors</li><li>HPPD: Hallucinogen Persisting Perception Disorder</li><li>Trepanation: how does it affect neurochemistry, if at all?</li><li>NBOMes (N-benzyl methoxy): What is it and how does it work?</li><li>Metabolizing LSD and related compounds</li><li>Chirality in psychedelics, especially LSD</li><li>Listener questions</li></ul><p><br/><b>Show notes:</b></p><p>Hamilton’s Pharmacopeia feat. Dr. Nichols: <a href='https://www.youtube.com/watch?v=7N4VoqeuK3s'>https://www.youtube.com/watch?v=7N4VoqeuK3s</a></p><p>Hallucinogens (2004) : <a href='https://pubmed.ncbi.nlm.nih.gov/14761703/'>https://pubmed.ncbi.nlm.nih.gov/14761703/</a></p><p>DEA 222 - <a href='https://dehs.umn.edu/using-dea-form-222-order-controlled-substances'>https://dehs.umn.edu/using-dea-form-222-order-controlled-substances</a></p><p>Mapping the Mind Talk: <a href='https://www.youtube.com/watch?v=6hfsIbib_50'>https://www.youtube.com/watch?v=6hfsIbib_50</a></p><p>MAPS Talk: <a href='https://www.youtube.com/watch?v=TxjCSKMbZBA'>https://www.youtube.com/watch?v=TxjCSKMbZBA</a></p><p>Telluride Keynot