January 2022 Discover CircRes

<p>This month on Episode 32 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the January 7 and January 21 issues of Circulation Research. This episode also features a conversation with Ms Natalie Harris and Dr Kathleen Caron from the University of North Carolina Chapel Hill about their study, VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling.</p> <p> </p> <p>Article highlights:<br />  </p> <p>Carlson, et al. AKAP18δ Controls CaMKIIδ Activity</p> <p> </p> <p>Gan, et al. sEV and Adipocyte ER Stress Following MI/R</p> <p> </p> <p>Khan, et al. Long-term Risk Prediction of Heart Failure</p> <p> </p> <p>Awan, et al. Wnt5a Is Essential for Cholesterol Homeostasis</p> <p> <br /> Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh. Today, I'm going to be highlighting the articles from our January issues of Circulation Research. I'm also going to speak with Ms Natalie Harris and Dr Kathleen Caron from the University of North Carolina Chapel Hill about their study, VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling.</p> <p> </p> <p>Cindy St. Hilaire:        The first article I want to share is titled AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and Ryanodine Receptors. The first and corresponding author for this article is Cathrine Carlson, and the study was conducted at University of Ohio. In cardiac muscle cells, calcium is continuously released and taken up by the sarcoplasmic reticulum to drive alternating contractions and relaxations. The kinase, CaMKII, regulates this calcium signaling via phosphorylation of the sarcoplasmic reticulum proteins ryanodine receptors also called RYR.</p> <p> </p> <p>Cindy St. Hilaire:         These receptors promote calcium release, and phospholamban promotes calcium uptake via th