January 2021 Discover CircRes

<p>This month on Episode 20 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the January 8 and January 22 issue of Circulation Research. This episode features an in-depth conversation with Drs Stefanie Dimmeler and Wesley Abplanalp from Goethe University in Frankfurt, Germany, regarding their study titled Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.</p> <p> </p> <p>Article highlights:<br />  </p> <p>Li, et al. FA Scaffold Genes Are Novel TAA Genes</p> <p> </p> <p>Z Perestrelo, et al. ECM Structure and Mechanics in Heart Failure</p> <p> </p> <p>Castranova, et al. Zebrafish Intracranial Lymphatics</p> <p> </p> <p>Rogers, et al. Computational Phenotypes for VT/VF Risk</p> <p> <br />  </p> <p>Cindy St. Hilaire:              Hi, and welcome to Discover CircRes, the podcast with the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire, from the Vascular Medicine Institute at the University of Pittsburgh. Today I'll be highlighting four articles selected from the January 8’th and January 22’nd issues of Circ Res. After the highlights, Dr Stephanie Dimmeler and Wesley Abplanalp at Goethe University in Frankfurt, Germany will join me to discuss their study, Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.</p> <p> </p> <p>Cindy St. Hilaire:              The first article I want to share is Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm. The first authors are Yang Li and Shijuan Gao, and the corresponding authors are Jie Du and Yulin Li from Beijing Institute of Heart, Blood and Lung Vessel Disease in Beijing, China. Thoracic aortic aneurysm is the localized expansion of the blood vessel. This expansion causes weakening of the vessel wall, causing it to rupture, which is a life-threatening emergency.</p> <p>Although there are several genetic mutations that lead to thoracic aortic aneurysms, more often thoracic aortic aneurysms occur as an iso