Inclisiran – How Does it Really Work?

<p>Inclisiran – How Does it Really Work?</p> <p>Guest: R. Scott Wright, M.D.</p> <p>Host: Stephen Kopecky, M.D. (<a href='http://twitter.com/DrSteveKopecky'>@DrSteveKopecky</a>)</p> <p>In 2021, the U.S. Food and Drug Administration (FDA) approved the use of inclisiran to lower low-density lipoprotein (LDL) cholesterol in people with atherosclerotic cardiovascular disease.</p> <p>Joining us today to discuss inclisiran is R. Scott Wright, M.D., a cardiologist at Mayo Clinic in Rochester, Minnesota. Dr. Wright was intimately involved in planning recent studies of inclisiran and reporting the results.</p> <p>Specific topics discussed:</p> <ul><li>How inclisiran works</li> <li>FDA-identified indications for use</li> <li>Administration and dosing</li> <li>Cost of the drug</li> <li>LDL cholesterol reduction results</li> <li>Initial and long-term side effects</li> <li>Long-term benefits and studies</li> <li>Inclisiran and lipoprotein (a)</li> <li>Off-target effects and drug-drug interaction monitoring</li> <li>The ideal patient and patients who are not appropriate to receive inclisiran</li> <li>Research outcomes for patients who are statin intolerant</li> </ul> <p>Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at <a href='https://cveducation.mayo.edu'>https://cveducation.mayo.edu</a> or on Twitter <a href='https://www.twitter.com/mayocliniccv'>@MayoClinicCV</a>.</p>