"How We Age: The Science of Longevity" (Professor Coleen Murphy, Princeton)

<p>Dr. Coleen Murphy is a prominent aging researcher and author of the upcoming book “How We Age: The Science of Longevity” from Princeton University Press. In this wide-ranging discussion, Coleen provides insights into her motivation for writing this book, key topics covered, and her unique perspective on the field.&nbsp;</p><p><strong>Key ideas:</strong></p><ul><li>Addressing ethical concerns about studying aging and longevity</li><li>Defining aging conceptually and how metrics like lifespan vs. healthspan are measured</li><li>Using genetics, transcriptomics and other tools to understand molecular changes in aging</li><li>The prominent role of reproduction and sex differences in aging</li><li>Theories on tradeoffs between reproduction and longevity</li><li>Genetics of aging pathways including insulin/IGF-1, mTOR, and sirtuins</li><li>Cellular processes involved in aging such as mitochondrial dysfunction, epigenetic changes, senescence</li><li>The importance of models like C. elegans and Drosophila in aging research</li><li>Ongoing research and future potential for interventions to increase healthspan</li><li>The challenge of complex science without excessive jargon</li><li>Highlighting critical contributions by women scientists in the field</li><li>Omitting personal lifestyle advice and focusing on evidence-based science</li><li>The rapid pace of advancement in biotech applications of longevity science</li></ul><br/><p><strong>Links:&nbsp;</strong></p><p>Email questions, comments, and feedback to <a href="mailto:podcast@bioagelabs.com" rel="noopener noreferrer" target="_blank">podcast@bioagelabs.com</a></p><p>Translating Aging on Twitter:<a href="https://twitter.com/BioAgePodcast" rel="noopener noreferrer" target="_blank"> @bioagepodcast</a></p><p>BioAge Labs Website<a href="https://bioagelabs.com/" rel="noopener noreferrer" target="_blank"> bioagelabs.com</a></p><p>BioAge Labs Twitter<a href="https://twitter.com/bioagelabs?lang=en" rel="noopener noreferrer" target="_blank"> @bioagelabs</a></p><p>BioAge Labs<a