Hacking the Complex System of Aging (Peter Fedichev, GERO)

<p>This week, we welcomes Peter Fedichev, an entrepreneur and scientist with over 20 years of experience in academic research and biotech business who has co-founded three biotech companies. He’s currently the co-founder &amp; CEO of GERO, a longevity startup on a mission to hack aging.&nbsp;</p><p>In this episode, Chris and Peter discuss GERO’s goal to accelerate our understanding of aging and create a therapy that will significantly extend a healthy human lifespan. First, they talk about the relationship between physics and biotech, and from there, the conversation moves to the importance of resilience in human and animal aging. Finally, Peter walks us through GERO’s drug discovery approach, how we can ‘hack’ complex dynamic systems and aging using AI, and shares his optimism about the future of aging research.</p><p><strong>The Finer Details of This Episode:&nbsp;</strong></p><ul><li>Discussing complex systems and aging</li><li>Understanding slower aging in some animals</li><li>Resilience and dynamic stability</li><li>The dynamic frailty indicator</li><li>Models of premature aging and slow aging</li><li>GERO’s drug discovery approach&nbsp;</li></ul><br/><p><strong>Quotes:&nbsp;</strong></p><p>“What we can do and what I think is very good to learn how to do in biology is to understand those universal properties that do not depend on fine details of life histories.”</p><p>“Obviously aging, that is a very slow process—so slow that almost everything averages out and people that are living under different conditions with totally different life histories are still living more or less the same long life.”</p><p>“It's easier to rejuvenate an animal which doesn't have any resilience because resilience means the ability to get back to the norm after the intervention. If you are resilient, either a bad effect like smoking or a good effect as your future aging drug will be small, and the more resilient you are, the smaller is the effect.”</p><p>“If you can only increase your lifespan once you're already unstable, the over