Ep. 172 VEXAS: A Mystery Syndrome

<p>While science and medicine have come a long way over the centuries, there are still illnesses that cannot be explained -- and many of them are autoinflammatory disorders. Many people all over the world have been inflicted with these disorders with no clear cause.</p> <p>But recently, scientists were able to find a mutation that can help explain what some of these people are going through, a mutation that led to the identification of an autoinflammatory disorder now known as VEXAS. Tune in to learn more!</p> <p>References:</p> <ul> <li><a href="https://www.nejm.org/doi/full/10.1056/nejmoa2026834"><u>https://www.nejm.org/doi/full/10.1056/nejmoa2026834</u></a></li> <li><a href="https://www.nature.com/articles/nrm.2017.83"><u>https://www.nature.com/articles/nrm.2017.83</u></a></li> <li><a href="https://www.sciencedirect.com/science/article/pii/S0962892413002274"><u>https://www.sciencedirect.com/science/article/pii/S0962892413002274</u></a></li> <li><a href="https://www.sciencedirect.com/science/article/pii/S0006497121010223"><u>https://www.sciencedirect.com/science/article/pii/S0006497121010223</u></a></li> <li><a href="https://journals.physiology.org/doi/abs/10.1152/physrev.00004.2022"><u>https://journals.physiology.org/doi/abs/10.1152/physrev.00004.2022</u></a></li> <li><a href="https://www.niams.nih.gov/labs/grayson-lab/vexas"><u>https://www.niams.nih.gov/labs/grayson-lab/vexas</u></a></li> <li><a href="https://jamanetwork.com/journals/jama/article-abstract/2800661"><u>https://jamanetwork.com/journals/jama/article-abstract/2800661</u></a></li> <li><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17893"><u>https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17893</u></a></li> <li><a href="https://www.nature.com/articles/s41375-022-01698-8"><u>https://www.nature.com/articles/s41375-022-01698-8</u></a></li> <li><a href="https://ashpublications.org/blood/article-abstract/140/8/927/485331/Ruxolitinib-is-more-effective-than-other-JAK"><u>https://ashpublications.org/blood/article-abstra