December 2021 Discover CircRes

<p>This month on Episode 31 of <em>Discover CircRes</em>, host Cynthia St. Hilaire highlights two original research articles featured in the December 3 issue of <em>Circulation Research</em>. This episode also features a conversation with Drs Xavier Revelo, and Jop van Berlo from the University of Minnesota about their study, <em>Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.</em></p> <p><em> </em></p> <div> <p><strong>Article highlights:</strong></p> </div> <p> </p> <div> <p>Tong, et al. <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319377">Alternative Mitophagy Protects Obesity Hearts</a></p> <p>Soetkamp, et al. <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316311">Myofilament Phosphorylation in CDC Treated HFpEF</a></p> <p> </p> </div> <p><strong>Cindy St. Hilaire:       </strong> Hi, and welcome to <em>Discover CircRes</em>, the podcast of the American Heart Association's journal, <em>Circulation Research</em>. I'm your host, Dr Cindy St. Hillaire from the Vascular Medicine Institute at the University of Pittsburgh. And today I'll be highlighting two articles presented in our December 3rd issue of CircRes, and I'll also speak with doctors, Xavier Revelo, and Jop van Berlo from University of Minnesota about their study, Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.</p> <p> </p> <p><strong>Cindy St. Hilaire:       </strong> The first article I want to share is titled, Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. The first doctor is Ming Ming Tong, and the corresponding author is Jun Sadoshima from Rutgers University. People with obesity or diabetes have an increased risk of developing cardiomyopathy, a condition which can eventually lead to heart failure. One of the major pathological features of obesity-related cardiomyopathy at the cellular level is a decrease in mitochondrial function. This decrease in mitochondrial function is likely due to a decrease in the canonical mitophagy