August 2022 Discover CircRes

<p>This month on Episode 39 of <em>Discover CircRes</em>, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.</p> <p> </p> <p><strong>Article highlights:</strong></p> <p> </p> <p>Jain, et al. <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.320530">Role of UPR in Platelets</a></p> <p> </p> <p>Orlich et al: <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321109">SRF Function in Mural Cells of the CNS</a></p> <p> </p> <p>Xue et al: <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321253">Gut Microbial IPA Inhibits Atherosclerosis</a></p> <p> </p> <p>Wang et al: <a href= "https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.319955">Endothelial ETS1 on Heart Development</a></p> <p> </p> <p><strong>Cindy St. Hilaire:       </strong> Hi, welcome to <em>Discover CircRes</em>, the podcast of the American Heart Association's journal <em>Circulation Research</em>. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting articles from our August 5th and August 19th issues of <em>Circulation Research</em>. I'm also going to have a chat with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University about their study, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension.</p> <p> </p> <p>But before I get to the interview, I first want to share an article from our August 5th issue, and that article is titled, Unfolded Protein Response Differentially Modulates the Platelet Phenotype. The first author of this study is Kanika Jain and the corresponding author is John Hwa from Yale University. Self-stress can lead to protein misfolding, and the accumula