At the Cutting Edge of Computational Precision Medicine, with Rafael Rosengarten

<p>Genialis, led by CEO Rafael Rosengarten, is one of the companies working toward a future where there are no more one-size-fits-all drugs—where, instead, every patient gets matched with the best drug for them based on their disease subtype, as measured by gene-sequence and gene-expression data. Analyzing that data—what Rosengarten calls "computational precision medicine"—is already helping drug developers identify the patients who are most likely to respond to experimental medicines. Not long  from now, the same technology could help doctors diagnose patients in the clinic, and/or feed back into drug discovery by providing more biological targets for biopharma companies to hit.</p><p>"Our commitment to biomarker-driven drug development is very principled," Rosengarten tells Harry. "There are some amazing drugs out there that, when they work, work miracles. But they don't work that often. Some work in maybe 15 percent of the patients or 20 percent. If you could tell which of those patients are going to respond, then at least the ones who aren't can seek other options, and we would know that we've got to develop [new] drugs for the others." </p><p><strong>Please rate and review The Harry Glorikian Show on Apple Podcasts! </strong>Here's how to do that from an iPhone, iPad, or iPod touch:</p><p><strong>1. </strong>Open the Podcasts app on your iPhone, iPad, or Mac. </p><p><strong>2. </strong>Navigate to The Harry Glorikian Show podcast. You can find it by searching for it or selecting it from your library. Just note that you'll have to go to the series page which shows all the episodes, not just the page for a single episode.</p><p><strong>3. </strong>Scroll down to find the subhead titled "Ratings & Reviews."</p><p><strong>4. </strong>Under one of the highlighted reviews, select "Write a Review."</p><p><strong>5. </strong>Next, select a star rating at the top — you have the option of choosing between one and five stars. </p><p><strong>6. </strong>Using the text box at the top, write a title for your review. Then,