77. Combination therapies and serendipity

<p>Through a discussion of combination therapies, Dodi and Conor delve into the mysterious power of the human microbiome, and antimicrobial resistance. With evidence of the microbiome being a key factor in fighting diseases, this episode highlights the importance of understanding and treating the microbiome and its potential to improve lives. Tune in to find out more and explore the possibilities of the microbiome with Dr Saman Maleki, and the power of serendipity with Prof Pete Dedon! </p> <p><a href="https://www.cytivalifesciences.com/en/us/behind-biopharma/stories/combination-therapies-and-serendipity-10002" target="_blank" rel="noopener noreferer">Transcript</a></p> <p><br></p> <p><strong>Show notes</strong></p> <p><a href="https://doi.org/10.1038/s41591-023-02453-x" target="_blank" rel="noopener noreferer">Routy, B., Lenehan, J.G., Miller, W.H. et al. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nat Med 29, 2121–2132 (2023). </a></p> <p><a href="https://news.mit.edu/2023/novel-combination-therapy-counter-antibiotic-resistance-0626" target="_blank" rel="noopener noreferer">A novel combination therapy counters antibiotic-resistant Mycobacterium abscessus infections (MIT news)</a></p> <p><a href="https://www.sciencenews.org/article/blight-future-pandemic-fungus-book" target="_blank" rel="noopener noreferer">&#39;Blight&#39; warns that a future pandemic could start with a fungus (sciencenews.org)</a></p> <p><a href="https://doi.org/10.1038/s41564-023-01372-4" target="_blank" rel="noopener noreferer">Hildebrandt, T., Peyser, D. The gut microbiome in anorexia nervosa. Nat Microbiol 8, 760–761 (2023). </a></p> <p><br></p> <p><strong>Keywords</strong>: <em>microbiome, patients, immunotherapy, immune system, cancer, study, people, combination therapy, tumor, immuno-oncology, fungus, fecal transplant, anorexia nervosa, oncology, higher bmi</em></p>