#58 B cell maturation and class switching with Hamish King

<p>In this episode, we learn about B cell maturation and class switching from <a href="https://twitter.com/hamish_king">Hamish King</a>. Hamish recently published a <a href="https://immunology.sciencemag.org/content/6/56/eabe6291">paper</a> on this subject in Science Immunology, where he and his coauthors analyzed gene expression and antibody repertoire data from human tonsils. In the episode Hamish talks about some of the interesting B cell states he uncovered and shares his thoughts on questions such as «When does a B cell decide to class-switch?» and «Why is the antibody isotype correlated with its affinity?»</p> <p>Links:</p> <ul> <li><a href="https://immunology.sciencemag.org/content/6/56/eabe6291">Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics</a> (Hamish W. King, Nara Orban, John C. Riches, Andrew J. Clear, Gary Warnes, Sarah A. Teichmann, Louisa K. James) (paywalled by Science Immunology)</li> <li><a href="https://www.biorxiv.org/content/10.1101/2020.04.28.054775v2">Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation</a> (the preprint of the above Science Immunology paper)</li> <li><a href="https://www.tonsilimmune.org/">www.tonsilimmune.org: An immune cell atlas of the human tonsil and B cell maturation</a></li> </ul>