Chapter2 1 2. Multimodal Optical Imaging by Microendoscope

Abstract In the past decades, optical imaging field has been developing rapidly. Noninvasive imaging enabled by microendoscopes has become a promising tool for early cancer detection and imaging-guided surgery. In this chapter, we will mainly introduce most advances in the miniaturized microendoscope development, including photoacoustic, confocal fluorescence, multiphoton fluorescence, second-harmonic generation (SHG) label-free imaging, wide-field fluorescence, surface-enhanced Raman scattering (SERS) nanoparticle-based Raman spectroscopy. Enabled by the frontier micromachining techniques, micro-opto-electromechanical system (MOEMS)-based novel microendoscopes with various imaging modalities have been prototyped and further translated into clinics. The working principle of representative microendoscopes and optical imaging modalities will be introduced in detail.